Investigating Genome Methylation with Nanopore Sequencing

See methylation directly in native DNA, with no chemical conversion

Epigenetics, the study of chemical modifications that can alter phenotype without altering nucleotide sequence, is significant for a wide range of fields, from developmental biology to disease research. The most well-characterized and widely studied epigenetic modification is 5-methylcytosine (5mC) DNA methylation. While many methods exist for analyzing genomic methylation, traditional techniques present limitations. For example, methylation cannot be sequenced from PCR products, meaning that legacy short-read sequencing technology must infer the presence of methylation via chemically treating DNA samples prior to sequencing.

In this guide from Oxford Nanopore Technologies, discover how Nanopore sequencing enables the direct detection of intact methylation alongside nucleotide sequence without chemical conversion or additional library preparation steps.

FILL THE FORM BELOW









    By submitting this content request, I have legitimate interest in the content and agree that Oxford Nanopore | Biocompare, their partners, and the creators of any other content I have selected may contact me regarding news, products, and services that may be of interest to me.


    By downloading this content, you consent to Biocompare storing your email address and contact information and transmitting your contact information to the company that published the content. You also agree to receive email from Biocompare and the sponsor. You may request to be removed at any time.

    © An Imprint of coreinteltech | All rights reserved | Privacy Policy